HIV CURE SYMPOSIUM

11-12 September
Ghent, Belgium

Program


The program offers multiple perspectives on the HIV cure field, showcasing exciting recent research findings with potential for clinical translation. 

The conference sessions will present the latest research and foster discussion on:

• The establishment of the HIV reservoir

• The adaptive and innate immune responses associated with HIV control

• The molecular characteristics of the viral reservoirs 

• The development of new therapies


MONDAY 11 SEPTEMBER 2023
12.30-13.00Registration
13.00-13.10Welcome and Introduction
13.10-13.35KEYNOTE LECTURE
13.10-13.35HIV care versus cure in Europe anno 2023: mapping the impact of the Ukraine war
Milosz Parczewski, Pomeranian Medical University, Szczecin, Poland
13.35-14.00HIV RESERVOIR ESTABLISHMENT
13.35-14.00Within-host HIV reservoir dynamics
Zabrina Brumme, Simon Fraser University, Burnaby, Canada
14.00-14.25Inflammatory profile and viral reservoir after treatment initiation during acute HIV-1 infection
Jozefien De Clercq, HIV Cure Research Center, Ghent University, Ghent, Belgium
14.25-14.45Abstract Presentations
14.45-15.05Break
15.05-16.15HIV PERSISTENCE
15.05-15.30Proviruses in self-reactive CD4+ T-cells are a common source of residual HIV viremia
Francesco Simonetti, Johns Hopkins University, Maryland, United States
15.30-15.55Defining molecular pathways triggered by IL-10 and TGFb that drive HIV integration and persistence in Tfh cells in lymph nodes
Susan Ribeiro, Emory University, Atlanta, United States
15.55-16.15Abstract Presentations
16.15-16.35Break
16.35-18.10THE HIV RESERVOIR PHENOTYPE
16.35-17.00T-TRACE and HIV-seq enable single-cell multi-omics analysis of HIV reservoir cells
Nadia Roan, Gladstone Institutes and University of California San Francisco (UCSF), California, United States
17.00-17.25Immunological consequences of spontaneous HIV reservoir activity during suppressive ART
Daniel Kaufmann, University of Lausanne, Lausanne, Switzerland
17.25-17.50HIV silencing and cell survival signatures in infected T-cell reservoirs
Eli Boritz, NIAID Vaccine Research Center, Bethesda, United States
17.50-18.10Abstract Presentations
18.10-19.30NETWORK RECEPTION
TUESDAY 12 SEPTEMBER 2023
08.30-09.00Registration
09.00-09.40KEYNOTE LECTURE
09.00-09.40Multi-omics dissection of mechanisms of HIV persistence and immune dysfunction
Rafick-Pierre Sekaly, Emory University, Atlanta, United States
09.40-10.50CHARACTERISTICS OF THE IMMUNE SYSTEM AND THE HIV-1 RESERVOIR IN THE 2000HIV COHORT
09.40-10.05Virological aspects of fast and slow progressors in the 2000HIV cohort
Linos Vandekerckhove, Ghent University, Belgium
10.05-10.30Monocytes of HIV-1 elite controllers and relatives show enhanced trained immunity
Mihai Netea, Radboud University Medical Center, The Netherlands
10.30-10.50Abstract Presentations
10.50-11.30Poster Session + Break
11.30-12.40HIV-1 POST TREATMENT CONTROL
11.30-11.55Single Infusion of STEM like CCR5-modified CD4 T cells provide long-term HIV control
Ashish Sharma, Emory University, Atlanta, United States
11.55-12.20HIV post-treatment controllers have distinct immunological and virological features
Jonathan Li, Brigham and Women’s Hospital, Harvard Medical School, Boston, United States
12.20-12.40Abstract Presentations
12.40-14.00Lunch
14.00-15.00SATELLITE SYMPOSIUM
14.00-15.00Innovating towards a Cure: Gilead’s Immunotherapy Strategy
Elena Vendrame, Gilead Sciences, California, United States
15.00-16.25DESIGNING THERAPEUTIC OPTIONS FOR HIV CONTROL
15.00-15.25Soluble T cell receptor bispecific biologics for HIV
Lucy Dorrell, Immunocore and University of Oxford, United Kingdom
15.25-15.50Genetic editing of B cells aiming for an HIV cure
Anne Galy, ART-TG Inserm, Corbeil-Essonnes, France
15.50-16.10Abstract Presentations
16.10-16.30Break
16.30-17.45CORRELATES OF HIV CONTROL AND PERSISTENCE
16.30-16.55Combination Immunotherapy and Post-Interventional Control
Steven Deeks, UCSF San Francisco, United States
16.55-17.20HIV control in antibody and combination therapy cure studies
Martin Tolstrup, Aarhus University, Denmark
17.20-17.40Abstract Presentations
17.40-17.45Closing remarks