Every year in September, the HIV Cure Research Center organizes a lively symposium in the picturesque city of Ghent, Belgium. Since the pandemic outbreak of SARS-CoV-2, the lab has invested heavily in the initiation of key research in COVID-19 and a symposium can not be organized as before. Therefore, we decided to switch to a hybrid HIV-SARS-CoV-2 online symposium, which will take place the 22nd of October, in which we discuss key aspects of COVID-19 pathogenesis and HIV cure.

We will walk you through the basic principles of COVID-19 pathophysiology, animal models for COVID-19 and COVID-19 protection by nanobodies and a vaccine. In addition, we will of course focus on HIV reservoirs and cure.

Latent HIV reservoir is able to refuel infection once the treatment is stopped and therefore a better understanding of both, the composition and the size of this reservoir will be important to aid the development of cure strategies as well as to monitor the efficacy of therapeutic interventions to reduce the HIV reservoir. Therefore, we will address key aspects of viral rebound and how to monitor it. Finally, we will discuss the status of HIV cure clinical trials with emphasis on novel immunotherapeutic approaches.

The HIV and SARS-CoV-2 hybrid symposium will comprehensively summarizes the state of the art in COVID-19 and HIV cure strategies.

Program

SARS-CoV-2 HOT TOPICS - Chaired by Sarah Gerlo and Wojciech Witkowski
09.00 - 09.05

Welcome and Introduction

Linos Vandekerckhove, Ghent University Hospital, Ghent, Belgium

09.05 - 09.30

From HIV to SARS-CoV-2, from one pandemia to another

Nathan Clumeck, Saint-Pierre University Hospital-ULB, Belgium

Q&A

09.30 - 09.55

COVID-19 diseases and opportunities for immunotherapy

Bart Lambrecht, Ghent University, Belgium

Q&A

09.55 - 10.20

COVID-19 vaccine development efforts at J&J

Hanneke Schuitemaker, Global Head Viral Vaccines Discovery & Translational Medicine, Janssen Vaccines & Prevention,

Professor in Virology at Amsterdam University Medical Center

Q&A

10.20 - 10.45

Break

SARS-CoV-2 THERAPEUTIC APPROACHES AND SOCIETAL IMPACT - Chaired by Steven Callens and Kevin Ariën
10.45 - 11.10

Animal models for SARS-CoV-2 compound and vaccine development screening

Johan Neyts, KU Leuven, Leuven, Belgium

Q&A

11.10 - 11.35

Nanobodies to treat SARS-CoV-2 moving towards clinical trials

Xavier Saelens, VIB and Ghent University, Ghent, Belgium

Q&A

11.35 - 12.00

Balance between COVID-19 diseases and societal impact

Lieven Annemans, Ghent University and Brussels University (VUB), Belgium

Q&A

12.00 - 13.00

Break/Satellite Symposium

Remdesivir for the treatment of COVID-19: Tomas Cihlar (Vice President Discovery Virology, Gilead Sciences)

Gilead’s HIV Cure Strategy: Wade Blair (Executive Director Discovery Virology, Gilead Sciences)

UNMASKING THE HIV VIRAL RESERVOIR - Chaired by Linos Vandekerckhove and Marion Pardons
13.00 - 13.25

Distinct viral reservoirs in individuals with spontaneous control of HIV-1

Mathias Lichterfeld, Harvard Medical School, Boston, US

Q&A

13.25 - 13.50

How to link clonal proliferation, intact viral sequences and HIV-1 viral rebound

Basiel Cole, Ghent University, Ghent, Belgium

Q&A

13.50 - 14.15

Implementing HIV-1 intact proviral assays in clinical trials and clinical practice

Robert Siliciano, Johns Hopkins University, Maryland, US

Q&A

14.15 - 14.30

Break

IMMUNE STRATEGIES FOR SARS-CoV-2 AND HIV - Chaired by Guido Vanham and Gilles Darcis
14.30 - 14.55

TCR adapted therapies to cure HIV-1

Lucy Dorrell, University of Oxford, Oxford, UK

Q&A

14.55 - 15.20

Immunocorrelates of SARS-CoV-2 protection

Susan P. Ribeiro, Emory University, Atlanta, US

Q&A

15.20 - 15.45

Current status on HIV-1 Cure clinical trials

Linos Vandekerckhove, Ghent University and Ghent University Hospital, Ghent, Belgium

Q&A

15.45 - 16.00

Break

16.00 - 16.15

Closing and voting results

Linos Vandekerckhove, Ghent University and Ghent University Hospital, Ghent, Belgium

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WERELDWIJD LEVEN 37 MILJOEN MENSEN MET HIV. STEUN HET FONDS HIV ONTRAFELEN en Help hen.

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