The program offers multiple perspectives on the HIV cure field, showcasing exciting recent research findings with potential for clinical translation.
The conference sessions will present the latest research and foster discussion on:
• The establishment of the HIV reservoir
• The adaptive and innate immune responses associated with HIV control
• The molecular characteristics of the viral reservoirs
• The development of new therapies
| SUNDAY 22 SEPTEMBER 2024 | |
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| OPENING HIV CURE SYMPOSIUM - KEYNOTE LECTURE | |
| 18.00-18.30 | Future directions for HIV Cure research Ole Sogaard, Aarhus University, Denmark |
| 18.30-19.00 | 2000HIV Study Andre van der Ven, Radboud UMC, The Netherlands |
| 19.00-19.45 | Patient perspective on HIV cure trials |
| 19.45-21.00 | Opening Reception |
| MONDAY 23 SEPTEMBER 2024 | |
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| SESSION 1 – ‘VIRAL INTEGRATION’: CHROMOSOMAL ARCHITECTURE | |
| 08.30-08.55 | HIV targeted integration in the context of chromatin structure Monsef Benkirane, Research Director CNRS, France |
| 08.55-09.20 | Integration site selection, genomic features of integration sites and impact of viral expression Angela Ciuffi, CHUV, Switzerland |
| 09.20-09.45 | Establishment of the viral reservoir during early infection Linos Vandekerckhove, Ghent University, Belgium |
| 09.45-10.10 | Immune selection of proviral DNA by CTL responses Brad Jones, Weill Cornell Medicine, USA |
| 10.15-10.45 | Break |
| SESSION 2 – COMPOSITION AND EVOLUTION OF THE VIRAL RESERVOIR | |
| 10.45-11.10 | Composition of the reservoir in the 2000HIV study: clinical data and biomarker analysis Mareva Delporte, Ghent University, Belgium |
| 11.10-11.35 | HIV Expression in Infected T cell Clones Mary Kearney, National Institue for Medical Research, Australia |
| 11.35-12.00 | Understanding the viro-immunological mechanisms contributing to HIV control during an analytical treatment interruption Sarah Palmer, The Westmead Institute for Medical Research, Australia |
| 12.00-12.25 | HIV diversity, tropism and immunological control in the 2000HIV study Kavita Mehta and Sofie De Braekeleer, Ghent University, Belgium |
| 12.30-14.00 | Lunch |
| SESSION 3 – REACTIVATION OF THE VIRAL RESERVOIR | |
| 14.00-14.25 | Reactivation of the viral reservoir by TAT LNPs Daniel Claiborne, The Wistar Institute, USA |
| 14.25-14.50 | Role of immune homeostasis in reaching a low reservoir Ashish Sharma, Emory University, USA |
| 14.50-15.40 | Block and lock versus shock and kill Zeger Debyser versus Carine Van Lint, Belgium |
| 15.40-16.10 | Break |
| SESSION 4– INSPIRATIONAL SESSION | |
| 16.10-17.00 | Satellite ViiV Healthcare |
| 17.00-17.45 | Lessons learned from the cancer field Rafick Sékaly, Emory University, USA |
| 17.45-18.30 | Conclusion |
| 18.30-20.30 | Poster session and dining and wining |
| TUESDAY 24 SEPTEMBER 2024 | |
|---|---|
| SESSION 5 – CELL AND IMMUNE BASED THERAPY TO ELIMINATE THE RESERVOIR | |
| 08.30-08.55 | The kitchen sink study Michael Pelluso |
| 08.55-09.20 | Increasing longevity of CAR T cells after infusion Wojciech Witkowski, Ghent University, Belgium |
| 09.20-09.45 | Implementing Gene therapy studies in Africa Cissy Kytyo |
| 09.45-10.10 | TBC TBC |
| 10.10-10.50 | Break |
| SESSION 6 – MODULATION OF INNATE IMMUNITY | |
| 10.50-11.15 | Immune aging Mihai Netea, Radboud UMC, The Netherlands |
| 11.15-11.40 | Regulation of cytokine responses in PLHIV Yang Li |
| 11.40-12.05 | Innate memory in HIV controllers Jéssica dos Santos, Radboud UMC, The Netherlands |
| 12.05-12.30 | Impact of food intake on immune system and inflammation Quirijn de Mast, Radboud UMC, The Netherlands |
| 12.30-14.00 | Lunch |
| SESSION 7 – MODULATION OF INNATE IMMUNITY | |
| 14.00-14.25 | Peristent inflammation in people treated during acute infection Sarah Gerlo, Ghent University, Belgium |
| 14.25-14.50 | CMV infection in PLWH Yang |
| 14.50-15.15 | Innate immunity and comorbidities Twan Otten, Radboud UMC, The Netherlands |
| 15.15-15.45 | Microbiome and HIV Jing Fu |
| 15.45-16.15 | Break |
| SESSION 8– CELL AND IMMUNE BASED THERAPY TO ELIMINATE THE RESERVOIR | |
| 16.15-16.40 | Assessing immunogenicity barriers of the HIV-1 envelope trimer Rogier Sanders, Amsterdam UMC, The Netherlands |
| 16.40-17.05 | TBC TBC |
| 17.05-17.30 | TBC TBC |
| 17.30-20.30 | Speakers dinner |
| WEDNESDAY 25 SEPTEMBER 2024 | |
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| SESSION 9 – HIV PERSISTENCE IN TISSUE | |
| 08.30-08.55 | CD4+ T cells in HIV: A Friend or a Foe? Costas Petrovas, CHUV, Switzerland |
| 08.55-09.20 | Translation competent virus in lymph node and gut Marion Pardons, Ghent University, Belgium |
| 09.20-09.45 | Role of tissue NK cells in HIV persistence Maria Buzon, Vall d’Hebron Institute of Research (VHIR), Spain |
| 09.45-10.15 | Polyfunctional T cell responses in nonhuman primates Susan Pereira, Emory University, Belgium |
| 10.15-10.45 | Break |
| SESSION 10 – KEYNOTES AND FUTURE PERSPECTIVES | |
| 10.45-11.25 | TBC TBC |
| 11.25-12.05 | Role of ILCs in HIV persistence TBC |
| 12.05-12.25 | Future perspectives towards cure Jan van Lunzen |
| 12.25-12.35 | Closing remarks |